Mark A. Levine, MD b. 1952 Hall of Fame 2019 Mark Levine, MD, is Senior Investigator, Molecular and Clinical Nutrition Section, Digestive Disease Branch of the National Institute of Diabetes and Digestive and Kidney Diseases. A graduate of Harvard Medical School (MD, 1977), he completed his internship and residency at Osler Medical Service, Johns Hopkins Hospital (1977-1980), followed by a NIH Fellowship in Endocrinology and Metabolism, Inter-institute Endocrinology Training Program (1980-1983). Dr. Levine’s laboratory at NIDDK conducts basic, translational, and clinical research which aims to determine optimal nutrition in health, disease, and treatment. His research focuses on vitamin C (ascorbic acid) as a model nutrient, to determine how specific vitamin C functions relate to nutrient concentration in vitro and in vivo. Dr. Levine’s laboratory seeks a functional basis for nutrient recommendations, rather than relying on preventing deficiency - the previous method used for many years. Many countries base their recommended dietary allowances (RDAs) for vitamin C on his laboratory’s work. Ongoing multiple clinical trials in cancer and sepsis using pharmacologic ascorbic acid are based on their work. In 2006, Dr. Levine coauthored "Intravenously administered vitamin C as cancer therapy: three cases" (CMAJ 174 (7) 937-942) with Hugh Riordan and John Hoffer, which concluded: "Accumulated data confer some degree of biological and clinical plausibility to the notion that high-dose intravenous vitamin C therapy may have anti-tumour effects in certain cancers." Dr. Levine’s research has benefitted the public by providing new ways to: (1) prevent disease and optimize health through nutrition; (2) treat cancer with minimal side effects; (3) slow glucose absorption as an added treatment for obesity and diabetes; (4) prevent or delay complications of diabetes; and (5) improve the collection or storage of red blood cells for transfusion. For more information, please visit: https://irp.nih.gov/pi/mark-levine We welcome Mark Levine into the Orthomolecular Medicine Hall of Fame.