onas, Rapoza and Blair1 reported that niacinamide was helpful in the treatment of osteoarthritis. Seventy two patients were divided by random selection into two groups. One group received the vitamin -i.nd other placebo. After twelve weeks they found that the niacinamide subjects improved by 29% and the placebo group worsened by 10%. Pain levels remained the same but on niacinamide patients were able to reduce their anti-inflammatory medication by 13%. This vitamin decreased erythrocyte sedimentation rate, increased joint mobility by 4.5 degrees over the control and side effects were mild. They concluded that niacinamide may have a role in the treatment of osteoarthritis.